THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人:
KITAJEWSKI, JAN,SHAWBER, CARRIE
申请号：
NZ59149209
公开号：
NZ591492A
申请日:
2009.08.21
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a fusion protein comprising a signal peptide, EGF repeats 1-X of the extracellular domain of human Notch3 receptor protein wherein X is any integer from 12 to 34, and an Fc portion of an antibody bound thereto, wherein the signal peptide is the signal peptide of Notch3 or IgG Heavy Chain. Further disclosed is a fusion protein comprising a signal peptide, EGF repeats 1-X of the extracellular domain of human Notch3 receptor protein wherein X is any integer from 1 to 10, and an Fc portion of an antibody bound thereto, wherein the signal peptide is the signal peptide of Notch3 or IgG Heavy Chain. Further disclosed is a fusion protein comprising a signal peptide, at least 12 EGF repeats of the extracellular domain of human Notch3 receptor, and an Fc portion of an antibody bound thereto, wherein the signal peptide is the signal peptide of Notch3 or IgG Heavy Chain. Further disclosed is a fusion protein comprising a signal peptide, EGF repeats of the extracellular domain of human Notch3 receptor protein, wherein at least 12 EGF repeats are present, and an Fc portion of an antibody bound thereto, wherein the signal peptide is the signal peptide of Notch3 or IgG Heavy Chain.
