#$%^&*AU2020102037A420201008.pdf#####Abstract This research lies in the field of ecological agriculture and medical science. It is a method of improving the inhibitory activity of a-glucosidase from mulberry leaves by biological fermentation. This method consists of the following steps. Firstly, we choose fresh mulberry leaves and pretreat them. Secondly, the inoculum of Lactobacillus plantarum, Trichoderma, Pleurotus eryngii and so on, are prepared separately and one or more of them are inoculated on fresh mulberry leaf to conduct the fermentation; Thirdly, the active ingredients in the fermented mulberry leaves will be extracted. Finally, The inhibition rate of a-glucosidase in vitro of mulberry leaf extract will be determined. 1