БЛУМ Лэйрд (US),ДЖИЛЛ Давиндер (US),ВУГМЕЙСТЕР Юлия (US),ЯНГ Дебора А. (US),О'ТУЛ Маргот (US),ГЬЮЭЙ Хит М. (US),ЭДКИНС Карисса К. (US),УИВЕР Эми Арлин (US),ДЖАИН Садхана (US),АРАИ Майя (US),ОТУЛ Маргот (US)
申请号：
RU2010152689/15
公开号：
RU2010152689A
申请日:
2009.05.26
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A method of treating or preventing an IL-21R-related disorder in an individual, comprising administering to the individual a binding protein or antigen-binding fragment thereof that specifically binds to human IL-21R in an amount sufficient to inhibit or reduce the activity of immune system cells in the individual thus providing treatment or prophylaxis of the disorder, wherein the binding protein or antigen-binding fragment thereof contains at least one amino acid sequence that is at least approximately 95% identical to the amino acid sequence (s) selected from the group consisting of SEQ ID NO: 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42 , 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92 , 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142 , 144, 146, 148, 150, 152, 154, 156, 158, 160, 162, 165-168, 171-193, 213-229, 240, 242, 244, 246 and 248.! 2. The binding protein or antigen binding fragment according to claim 1, where the binding protein or antigen binding fragment is an antibody. ! 3. The binding protein or antigen binding fragment according to claim 1, where the binding protein or antigen binding fragment is scFv. ! 4. The binding protein or antigen binding fragment according to claim 1, where the binding protein or antigen binding fragment is a VH. ! 5. The binding protein or antigen binding fragment according to claim 1, where the binding protein or antigen binding fragment is a VL. ! 6. The binding protein or antigen binding fragment according to claim 1, where the binding protein or antigen binding fragment is a CDR. ! 7. A method for treating or preventing an IL-21R-related disorder in an Indian1. Способ лечения или профилактики нарушения, связанного с IL-21R, у индивидуума, включающий введение индивидууму связывающего белка или его антигенсвязывающего фрагмента, который специфически связывается с IL-21R человека, в
