Christopher McKinnon LEE,Thomas Claiborne LOVELACE,Joseph Alexander MOORE, III,Daniel Logan KIRSCHNER
申请号：
US16458267
公开号：
US20200023003A1
申请日:
2019.07.01
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Described herein is anhydrous sodium thiosulfate, methods for synthesizing anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur, and cetylpyridinium chloride. The anhydrous sodium thiosulfate is formulated into a pharmaceutical composition comprising a buffer and solvent. These compositions are useful for eliminating or reducing ototoxicity in pediatric patients receiving platinum based chemotherapeutics.
