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ЭМУЛЬСИОННЫЙ СПОСОБ ПОЛУЧЕНИЯ МИКРОЧАСТИЦ С НИЗКИМ СОДЕРЖАНИЕМ ОСТАТОЧНОГО РАСТВОРИТЕЛЯ
专利权人:
ЭВОНИК КОРПОРЕЙШН (US)
发明人:
ПЕРКИНС Бренда Х. (US),ПЭТТЭНЕЙК Асима (US)
申请号:
RU2013119810/15
公开号:
RU2013119810A
申请日:
2011.09.28
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. An emulsion comprising: a discontinuous phase comprising: a biocompatible polymer dispersed or dissolved in a solvent of the dispersed phase containing the C-Sgalogenirovanny alkane, ethyl acetate or a combination thereof idispersionnuyu medium comprising: a mixture of surfactant and a non-polar alkane wherein the surfactant mixture comprises at least 2 wt% of a nonpolar alkane, dissolved or dispersed therein. wherein the dispersed phase is dispersed in a dispersion srede.2. Emulsion according to claim 1, wherein the surfactant comprises a mixture of sorbitan monostearate, sorbitan monooleate, polyoxyethylene sorbitan monooleate or kombinatsiyu.3. Emulsion according to claim 1, wherein the biocompatible polymer comprises poly (lactide), poly (glycolide), poly (lactide-co-glycolide), poly (caprolactone), poly (lactide-co-caprolactone), polyethylene glycol or a copolymer thereof, a combination of or smes.4. Emulsion according to claim 1, wherein the discontinuous phase further comprises a biologically active agent.5. Emulsion according to claim 4, wherein the biologically active agent is vodorastvorimym.6. Emulsion according to claim 4, wherein the biologically active agent is a oligopeptid.7. Emulsion according to claim 6, wherein the biologically active agent is a oktreotid.8. Emulsion according to claim 1, wherein the dispersed phase comprises at least 10 wt.% Polimera.9 biocompatible. Emulsion according to claim 1, wherein the dispersed phase solvent comprises methylene chloride, chloroform, carbon tetrachloride, ethylene dichloride, ethylene chloride, 2,2,2-trichloroethane or smes.10. Emulsion according to claim 1, wherein the dispersed solvent phase comprises etilatsetat.11. Emulsion according to any one of claims 1-10, wherein the non-polar alkane with1. Эмульсия, содержащая:дисперсную фазу, содержащую: биосовместимый полимер, диспергированный или растворенный в растворителе дисперсной фазы, содержащем С1-С4 галогенированный алкан, этилацетат или их комбинац
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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