MONOCLONAL ANTIBODY HAVING IMMUNOSUPPRESSIVE ACTIVITY OR FRAGMENT TO WHICH ANTIGEN THEREOF IS BONDED农业专利-农业学术服务平台

发明人:: SATO, SHUJI,GOTO, TAKESHI,GOTO, SHIGERU,NAKANO, TOSHIAKI,OHMORI, NAOYA,CHIANG, KUEICHEN,SHIMADA, YAYOI,MORI, KENJI,MIYAGI, TAKAMITSU

摘要：: The present invention relates to a monoclonal antibody having excellent immunosuppressive activity or an antigen binding fragment thereof. More specifically, the present invention relates to a monoclonal antibody or an antigen binding fragment thereof, which binds to a peptide consisting an amino acid sequence represented by SSVLYGGPPSAA (SEQ ID NO: 1) or a conjugate of the peptide and a pharmaceutically acceptable carrier, the monoclonal antibody or an antigen binding fragment thereof having a higher binding affinity for core histone than for histone H1.