Robert Baiocchi,Chenglong Li,Pui Kai Li,Fengting Yan
申请号:
US13518828
公开号:
US09044432B2
申请日:
2010.12.22
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Disclosed herein are compositions and methods for cancer detection and treatment. Compounds that inhibit PRMT5 are contemplated, as are pharmaceutical compositions comprising a therapeutically effective amount of at least one PRMT5 inhibitor. In some embodiments pharmaceutical compositions further comprising at least one HDAC inhibitor are contemplated. Methods of treating disorders in a mammal by inhibiting PRMT5 by administering to a mammal, a therapeutically effective amount of a PRMT5 inhibitor are also disclosed.