The present invention provides a biological graft material of cartilage tissue derived from mammalian. Through the process of multi-stage, antigenicity, to the cytotoxic pathogens and the risk of side effects is extremely low in living body at the time of transplantation, biological graft materials of the present invention, cartilage (mammal) non-human animals there is an advantage in the supply and Shutoku is smooth so used, the cost is cheaper at the time of application to live organ transplant, of excellent stability. [Selection] Figure 12本発明は哺乳類の軟骨組織由来の生体移植材を提供する。本発明に係る生体移植材は、多段階の処理工程を経ることにより、抗原性、病原体及び細胞毒性に対して、生体移植時に副作用の危険が極めて低く、ヒト以外の動物(哺乳類)の軟骨組織を用いるのでその収得や供給が円滑であり、生体移植に適用時に費用が安価であり、安定性に優れるという利点がある。【選択図】図12