REPROGRAMMING OF HUMAN ENDOTHELIUM INTO HEMATOPOIETIC MULTI-LINEAGE PROGENITORS BY DEFINED FACTORS

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专利权人:

CORNELL UNIVERSITY

发明人:

SANDLER, VLADISLAV M.,RAFII, SHAHIN

申请号：

EP14740745

公开号：

EP2946007A4

申请日:

2014.01.15

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The invention is directed to generation of hematopoietic multi-lineage progenitors (HMLPs) from endothelial cells (ECs) by effecting forced expression of certain transcription factors in the ECs and culturing the ECs in serum free media in the presence of endothelial feeder cells. The HMLPs generated in accordance with this invention can produce erythroid, lymphoid, myeloid, and megakaryocyte cells. These generated HMLPs can be used in therapeutic treatment of disorders including hematopoietic conditions.

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中国工程科技知识中心

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