THE PRESENT INVENTION RELATES TO FUSION PROTEINS COMPRISING AN ANTIGEN DERIVED FROM THE SO-CALLED TUMOUR REJECTION ANTIGEN PRAME (ALSO KNOWN AS DAGE) LINKED TO AN IMMUNOLOGICAL FUSION PARTNER WHICH PROVIDES T HELPER EPITOPES, SUCH AS, FOR EXAMPLE PROTEIN D FROM HAEMOPHILUS INFLUENZAE B, FUSION PARTNER PROTEINS COMPRISING FRAGMENTS OF PROTEIN D, METHODS FOR PREPARING THE SAME AND FOR FORMULATING VACCINES AND USE OF THE SAME FOR TREATING A RANGE OF CANCERS.