Compounds derived from benzaldehidos replaced, allosteric modulators of hemoglobin； Pharmaceutical composition that comprises； and Method for treating a condition associated with Oxygen deficiency Lung Disorder, such as cancer, ulcer, Stroke, Alzheimer's disease, among others.
INC.;GLOBAL BLOOD THERAPEUTICS, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;CYTOKINETICS
发明人:
METCALF BRIAN,CHUANG CHIHYUAN,WARRINGTON JEFREY,JACOBSON MATTHEW P,PAULVANNAN KUMAR,HU LAN,MORGAN BRADLEY
申请号：
CL2014001762
公开号：
CL2014001762A1
申请日:
2014.06.30
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
Provided are substituted benzaldehydes and derivatives thereof of formula (I) that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.<；p>；COMPUESTOS DERIVADOS DE BENZALDEHÍ；DO MODULADOR ALOSTÉ；RICO DE HEMOGLOBINA； COMPOSICIÓ；N FARMACÉ；UTICA； Ú；TILES EN EL TRATAMIENTO DE TRASTORNOS MEDIADOS POR HEMOGLOBINA Y TRASTORNOS QUE SE BENEFICIARÍ；AN DE OXIGENACIÓ；N INCREMENTADA AL TEJIDO TALES COMO ENFERMEDAD DE CÉ；LULA FALCIFORME, CÁ；NCER, ALZHEIMER<；/p>；
