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METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2-DEOXY-GUANOSINE (CEDG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEDG
专利权人:
发明人:
Samuel RAHBAR,Timothy W. SYNOLD,John TERMINI,Sarah SHUCK
申请号:
US15887857
公开号:
US20180338939A1
申请日:
2018.02.02
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Methods of quantifying a N2-(1-carboxyethyl)-2′-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of metabolic disorders or complications associated therewith, including diabetes, its associated complications, and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels is achieved by using liquid chromatography electrospray ionization tandem mass spectrometry.
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