Refers to a combination comprising the compound inhibitor (Enzyme bace cleavage of the beta amyloid precursor protein), N - [3 - [(4aR, 7aS) - 2 - amino - 4 - (5 - fluoropirimidin - 2 - il) - 4a, 5,6,7 - tetrahidropirrolo [3,4-d] [1.3 tiazin] - 7th (4H) - yl] - 4 - 5 - fluoro methoxy phenyl] pyrazine-2-carboxamide formula I or its pharmaceutically acceptable and a monoclonal anti Abeta n3pglu as b12l or r17l.This combination is useful in the treatment of Alzheimers diseaseSe refiere a una combinacion que comprende al compuesto inhibidor de BACE (enzima de escision de la proteina precursora beta-amiloide) N-[3-[(4aR,7aS)-2-amino-6-(5-fluoropirimidin-2-il)-4a,5,6,7-tetrahidropirrolo[3,4-d][1,3]tiazin-7a(4H)-il]4-fluoro-fenil]5-metoxi-pirazina-2-carboxamida de formula I o su farmaceuticamente aceptable y un anticuerpo monoclonal Abeta anti-N3pGlu tal como B12L o R17L. Dicha combinacion es util en el tratamiento de la enfermedad de Alzheimer
