CHEN FRANCINE ZHIFEN,JOHNSON LESLIE S.,LOO DERYK T.,MOORE PAUL A.,HUANG LING
申请号：
NZ70153911
公开号：
NZ701539A
申请日:
2011.03.01
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a B7-H3 binding molecule (BRCA69D), wherein the molecule is an isolated antibody, an immunoreactive fragment thereof, or a diabody which comprises a variable domain that specifically binds an extracellular domain of B7-H3, wherein said molecule: (a) binds to 4Ig and 2Ig isoforms of B7-H3 that is endogenously expressed on the surface of a cancer cell and (b) comprises the CDR sequences of KASQNVDTNVA, SASYRYS, QQYNNYPFT, FGMH, YISSDSSAIYYADTVK and GRENIYYGSRLDY.
