COMPOSE SE LIANT AU PPARG MAIS N'AGISSANT PAS COMME PROMOTEUR ET COMPOSITION PHARMACEUTIQUE POUR LE TRAITEMENT DE MALADIES ASSOCIEES AU PPARG CONTENANT CELUI-CI UTILISE COMME PRINCIPE ACTIF
LEE, IN HEE,CHAE, HEE IL,KIM, SE HOAN,MOON, SOON YOUNG,HA, TAE YOUNG,CHOI, HYO SUN,KIM, YOUNG SEOK,KIM, CHUN HWA,RHEE, JAE KEOL
申请号：
CA2938762
公开号：
CA2938762A1
申请日:
2015.02.27
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention relates to a compound inhibiting CDK5-mediated PPARG phosphorylation and a pharmaceutical composition for treating PPARG-related diseases containing the same as an active ingredient. A compound represented by chemical formula 1 or an optical isomer thereof according to the present invention binds to PPARG at a high affinity, but does not act as an agonist, thereby inducing no gene transcription； blocks CDK5, which is a cause of PPARG phosphorylation, thereby causing no side effects of existing anti-diabetics； can be formulated into drugs due to improved pharmacological properties thereof； and can be favorably used as a pharmaceutical composition for treating PPARG-related diseases due to an excellent treatment effect on PPARG-related diseases.
