Omiatek, Donna,Leifer, Franziska,Ong, Jane,Gupta, Renu,Li, Zhilli,Perkins, Walter,Malinin, Vladimir
申请号：
NZ70755113
公开号：
NZ707551A
申请日:
2013.12.02
申请国别(地区):
NZ
年份:
2019
代理人:
摘要：
The present invention relates a pharmaceutical composition comprising a plurality of particles comprising treprostinil, a cationic compound and a surfactant, wherein the cationic compound is net cationic, wherein the surfactant is distearoylphosphatidylethanolamine-PEG2000 (DSPE-PEG2000) and present at a mole percent ranging from about 20% to about 30%, and wherein the particles have an average diameter of about 50 nm or less. The formulations are suitable for use in an inhalation device, and for treating pulmonary hypertension and portopulmonary hypertension.
