Disclosed is a method of sealing or treating an acne lesion on a person's skin, the method comprising contacting the acne lesion with a styptic composition comprising an anti-acne agent and a sufficient amount of a styptic to seal the lesion within 30 seconds after topical application of the composition to the acne lesion, wherein the anti-acne agent is salicylic acid, benzoyl peroxide, benzoic acid, or tretinoin and the styptic is aluminum sulfate or potassium alum.