The invention relates to a preparation method for a hollow fiber membrane based on hydrophobic and hydrophilic polymers containing a non-water soluble antioxidant. In particular the invention relates to a preparation method for a hollow fiber membrane used for extracorporeal blood treatment. The hollow fiber membrane has improved biocompatibility in treating blood, in particular reduced complement activation, and cause a lower platelet loss during treating blood. Meanwhile, the elution of hydrophilic polymers from the lumen of the hollow fiber membrane is reduced.本發明涉及一種基於疏水性和親水性聚合物的中空纖維膜的製備方法，所述聚合物中含有非水溶性抗氧化劑。具體而言，本發明涉及一種用於體外血液處理的中空纖維膜的製備。與此同時，中空纖維膜在血液處理方面具有改善的生物相容性，具體為使得血液處理時補體活化降低和使得血小板損失減少。同時，也降低中空纖維膜內腔中的親水性聚合物的洗脫量。
