Disclosed is a therapeutic composition for improving small intestine health, wherein the composition is formulated for enteral administration and comprises threonine, valine, tryptophan, serine and tyrosine, as free amino acids； and water； wherein the composition does not comprise free amino acid glutamine or a glutamine-containing dipeptide, or, if free amino acid glutamine and/or a glutamine-containing dipeptide is present, the total concentration of the free amino acid glutamine and the glutamine-containing dipeptide is less than 50 mg/l； wherein the composition does not comprise glucose or, if glucose is present, the concentration of glucose is less than 1 g/l； and wherein the composition does not comprise free amino acid methionine or a methionine-containing dipeptide, or, if free amino acid methionine and/or a methionine containing dipeptide is present, the total concentration of the free amino acid methionine and the methionine-containing dipeptide is less than 100 mg/l. Also disclosed is the use of said composition for the manufacture of a medicament for treating a human subject having villous atrophy that is formulated for enteral administration.
