BIOCONJUGUES NON AGGLOMERANTS D'AMYLINE ET DE COMPOSES MIMETIQUES DE L'AMYLINE, COMPOSITIONS CONTENANT LESDITS CONJUGUES, LEUR PREPARATION ET LEUR UTILISATION
DA ROCHA E LIMA, LUIS MAURICIO TRAMBAIOLI,ROSADO, LUIZ HENRIQUE GUERREIRO,GUTERRES, MARIANA FERNANDES DE AVILA NETTO,FERREIRA, BRUNO MELO VIEIRA GONCALVES
申请号：
CA3008182
公开号：
CA3008182A1
申请日:
2016.12.14
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present disclosure concerns non-agglomerating bioconjugates of amylin, amylin-mimetic compounds, and combinations comprising the same, wherein said bioconjugate contains at least one acyl unit. Methodology of making and using are provided herein. In some embodiments, an instant non-agglomerating amylin bioconjugate can be used for treating a disease associated with a lack of natural production of amylin and/or deposition or accumulation of extracellular amyloid fibers, which contribute to the dysfunction or failure of systemic organs such as the pancreas or the brain.
