Van Berkel, Patricius Hendrikus Cornelis,Howard, Philip Wilson
申请号：
AU2016249877
公开号：
AU2016249877A1
申请日:
2016.04.15
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Site-specific antibody-drug conjugates are described, in particular conjugates comprising an antibody which binds PSMA, and which comprises an amino acid substitution of an interchain cysteine residue by an amino acid that is not cysteine and pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antiobody moiety, allows for improved safety and efficacy of the ADC.
