Vitaliy M. Sviripa,Wen Zhang,Chunming Liu,David Watt
申请号：
US14668865
公开号：
US09895324B2
申请日:
2015.03.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Halogenated diarylacetylenes, e.g., diarylacetylenes having at least one halo substituent in one aryl ring and an amine in the opposing aryl ring, can inhibit the proliferation of LS174T colon cancer cells through the inhibition of c-myc and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)). Such compounds are useful as antineoplastic agents.
