A dermal conditioning device for creating at feast one fissure, in a stratum corneum layer of an area of skirt, comprising: a non-invasive fissuring generator； a controller coupled to the non-invasive skin fissuring generator； a power supply coupled to the non-invasive skin fissuring generator and the controller； and a housing encasing the non-invasive skin fissuring generator and the controller, wherein the controller controls the non-invasive skin fissuring generator to: generate at least one signal, and apply the at least one signal to dehydrate the area of skin, and stress the external surface of the stratum corneum layer of the area of skin, the stress calibrated to produce a strain on the stratum corneum layer causing a formation of at least one fissure in the stratum corneum layer when the area of skin is dehydrated, while maintaining a pre-fissure immune status of the area of skin.
