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Anti-b7-h3 antibody
专利权人:
LIMITED;DAIICHI SANKYO COMPANY
发明人:
SHU, TAKAHASHI,TATSUJI, MATSUOKA,KENJI, MURAKAMI,TAKESHI, TAKIZAWA,KENJI, HIROTANI,ATSUSHI, URANO,KEISUKE, FUKUCHI,MITSUHIRO, YAZAWA
申请号:
TR201808018
公开号:
TR201808018T4
申请日:
2012.04.24
申请国别(地区):
TR
年份:
2018
代理人:
摘要:
Disclosed is an antibody characterised by having the following properties of: (a) specifically binding to B7-H3; (b) having an antibody-dependent phagocytosis (ADCP) activity; and cell-mediated (c) having an in vivo anti-tumour activity, or a functional fragment of the antibody, wherein said antibody or functional fragment thereof comprises: CDRH1 consisting of an amino acid sequence represented by NYVMH, CDRH2 consisting of an amino acid sequence represented by YINPYNDDVKYNEKFK, and CDRH3 consisting of an amino acid sequence represented by WGYYGSPLYYFDY as complementarity determining regions of the heavy chain; and comprises CDRL1 consisting of an amino acid sequence represented by RASSRLIYMH, CDRL2 consisting of an amino acid sequence represented by ATSNLAS, and CDRL3 consisting of an amino acid sequence represented by QQWNSNPPT as complementarity determining regions of the light chain. Also disclosed is the use of such an antibody for the manufacture of a medicament for treatment of cancer.Mevcut buluş, bir tümör üzerinde bir terapötik etkiye sahip olan bir antikor ile ilgilidir. Yani, buluş bir anti-tümör aktivite göstermesi için B7-H3'ü bağlayan bir antikor ile ilgilidir. Buluşun bir amacı, bir tümör üzerinde bir terapötik etkiye sahip olan bir farmasötik sağlamaktır. Bir anti-tümör aktivite göstermesi için B7-H3'ü bağlayan bir anti-B7-H3 antikoru elde etme ile, bir tümörü tedavi etmek için antikoru ve benzerlerini içeren bir farmasötik bileşim elde edilir.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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