GARDELLA, THOMAS J.,SHIMIZU, NAOTO,KRONENBERG, HENRY M.,POTTS, JOHN T., JR.
申请号：
CA2454275
公开号：
CA2454275C
申请日:
2002.07.19
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to conformationally constrained parathyroidhormone (PTH) analogs, and methods of preparing and using the PTH analogs. Theinvention provides novel PTH polypeptide derivatives containing amino acidsubstitutions at selected positions in the polypeptides. The inventionprovides derivatives of PTH (1-34), PTH(1-21), PTH(1-20), PTH(1-19), PTH(1-18), PTH(1-17), PTH(1-16), PTH(1-15), PTH(1-14), PTH(1-13), PTH(1-12), PTH(1-11) and PTH(1-1 0) polypeptides, wherein at least one residue in eachpolypeptide is a helix, preferably an a-helix, stabilizing residue. Theinvention also provides methods of making such peptides. Further, theinvention encompasses compositions and methods for use in limiting undesiredbone loss in a vertebrate at risk of such bone loss, in treating conditionsthat are characterized by undesired bone loss or by the need for bone growth,e.g. in treating fractures or cartilage disorders and for raising cAMP levelsin cells where deemed necessary.
