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Compositions comprising solanum tuberosum for lowering cytosolic NADH level to mimic calorie restriction
专利权人:
D. James Morré
发明人:
D. James Morré
申请号:
US12945520
公开号:
US09283257B2
申请日:
2010.11.12
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Embodiments herein relate to agents that mimic calorie restriction (CR) to extend life span, especially agents that lower the level of cytosolic NADH and increase the level of cytosolic NAD+ (relative to NADH) required to mimic calorie restriction that results in life span extension, at least in part by inhibition by NADH of SIR2, which is a key regulator of life span in both yeast and animals. NADH is a competitive inhibitor of SIR2, an NAD-requiring NAD-dependent histone deacetylase required for chromatin silencing and life-span extension. An overall reduction in NADH activates SIR2 and extends life span. The use of fluorescence measurements of NADH levels in a 96-well plate assay utilizing Bakers yeast (Saccharomyces cerevisiae) as a model to screen for agents and supplements that lower NADH levels is disclosed herein. A caloric restriction mimetic contains 1 part Mg2+ malate, 1 part turmeric and 98 parts dehydrated potato skins.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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d. james morré
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