BENDER, Johannes Caspar Mathias Elizabeth,BOERMAN, Marcel Alexander
申请号：
NLNL2015/050696
公开号：
WO2016/056901A1
申请日:
2015.10.05
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
The invention provides a process of preparing an adhesive haemostatic product, said process comprising the steps of: providing a porous solid substrate coating the substrate with a coating liquid that comprises an electrophilically activated polyoxazoline (EL-POX) and a solvent to produce a coated substrate, said EL-POX containing at least 2 reactive electrophilic groups removing the solvent from the coated substrate. The present process enables the application of an EL-POX coating that leaves the pore structure of the substrate largely intact so that the ability of the porous substrate to absorb body fluids, such as blood, remains essentially unaffected. The EL-POX coated haemostatic product obtained by the present process has excellent adhesive properties due to the presence of electrophilic reactive groups that are capable of reacting with e.g. amine groups that are naturally present in tissue, under the formation of covalent bonds. The present invention also provides a tissue-adhesive haemostatic product selected from a coated mesh, a coated foam and a coated powder, said haemostatic product comprising: a porous solid substrate having a porosity of at least 5vol.%.% and comprising an outer surface that comprises a nucleophilic polymer containing reactive nucleophilic groups an adhesive coating that covers at least a part of the solid substrate, said coating comprising an electrophilically activated polyoxazoline (EL-POX), said EL-POX containing on average at least 1 reactive electrophilic group.Linvention concerne un procédé de préparation dun produit hémostatique adhésif, ledit procédé comprenant les étapes consistant à : fournir un substrat solide poreux revêtir le substrat dun liquide de revêtement qui comprend une polyoxazoline activée de manière électrophile (EL-POX) et un solvant pour produire un substrat revêtu, ladite EL-POX contenant au moins 2 groupes électrophiles réactifs éliminer le solvant du substrat revêtu. Le procédé de linvention permet lappl
