David Reza Mittelstein,Morteza Gharib,Stefanie Heyden,Michael Ortiz,Mikhail G. Shapiro
申请号：
US15912359
公开号：
US20180256922A1
申请日:
2018.03.05
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at their resonance frequency (“oncotripsy”) are presented. The systems and methods result in the permeabilization, lysis, and/or death of targeted cell types by using ultrasonic harmonic excitations that have their frequency and pulse duration specifically tuned to disrupt the nuclear membrane of the targeted cells types by inducing a destructive vibrational response therein while leaving non-targeted cell types intact. Target cells may be neoplastic.
