DEWDNEY, NOLAN JAMES,TAYGERLY, JOSHUA PAUL GERGELY,KENNEDY-SMITH, JOSHUA,KONDRU, RAMA K.,LOE, BRADLEY E.,LOU, YAN,MCINTOSH, JOEL,OWENS, TIMOTHY D.,SOTH, MICHAEL,SWEENEY, ZACHARY KEVIN
申请号：
MYPI 2010003693
公开号：
MY158411A
申请日:
2009.01.27
申请国别(地区):
MY
年份:
2016
代理人:
摘要：
THIS APPLICATION DISCLOSES 5-PHENYL-1H-PYRIDIN-2-ONE AND 6-PHENYL-2H-PYRIDAZIN-3-ONE DERIVATIVES ACCORDING TO GENERIC FORMULAE I-III: WHEREIN, VARIABLES R, X, Y1, Y2, Y3, Y4, N AND M ARE DEFINED AS DESCRIBED HEREIN, WHICH INHIBIT BTK. THE COMPOUNDS DISCLOSED HEREIN ARE USEFUL TO MODULATE THE ACTIVITY OF BTK AND TREAT DISEASES ASSOCIATED WITH EXCESSIVE BTK ACTIVITY. THE COMPOUNDS ARE FURTHER USEFUL TO TREAT INFLAMMATORY AND AUTO IMMUNE DISEASES ASSOCIATED WITH ABERRANT B-CELL PROLIFERATION SUCH AS RHEUMATOID ARTHRITIS. ALSO DISCLOSED ARE COMPOSITIONS CONTAINING COMPOUNDS OF FORMULAE I-III AND AT LEAST ONE CARRIER, DILUENT OR EXCIPIENT. (NO SUITABLE FIGURE)
