The present technique relates to a wearable device and a power supply system capable of reducing the stress on a user in relation to power supply. A power generator is provided on the outer side surface or eye side surface of a contact lens type wearable device. The power generator generates power by chemical reaction with a substance contained in a secretion or body fluid of the user wearing the wearable device and a power management unit supplies each part of the wearable device with the power generated by the power generator. As such the power generator generates power using the secretion or body fluid of the user as fuel and thus can stably supply power while reducing the stress on the user in relation to power supply. The present technique can be applied to a contact lens type wearable device.