The invention composition comprising 0% to about 29% w/w of cis-clomiphene and about 100% to about 71% trans-clomiphene or analogs thereof for use as a single dose medicament to achieve pharmacologically effective blood concentration of testosterone over a period of time from 3 to 30 days in the patient. Preferably, the composition consists essentially of trans-clomiphene or an analog thereof, and, preferably the single dose is from about 5 to about 100 mg.
