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Amorphous form of stabilized agomelatine, process for its preparation and pharmaceutical compositions containing it
专利权人:
Shanghai Institute Of Pharmaceutical Industry;Les Laboratoires Servier
发明人:
LAFARGUE, David,LYNCH, Michael,POIRIER, Cécile,LETELLIER, Philippe,PEAN, Jean-Manuel,LUO, Ying,SHAN, Hanbin,SHEN, Yuhui
申请号:
ES13762107
公开号:
ES2659196T3
申请日:
2013.09.11
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Stabilized amorphous form of agomelatine, of formula (I): ** Formula ** characterized in that agomelatine is dispersed within a matrix as follows: - 30%, 40% or 50% by weight of agomelatine in Eudragit L100, - 30%, 35%, 40% or 50% by weight of agomelatine in Eudragit L100-55, - 30%, 35% or 40% by weight of agomelatine in Kollidon VA64, - 30%, 35% or 40% by weight of Agomelatine in Soluplus, - 30% or 40% by weight of agomelatine in polyvinyl acetate phthalate, - 30% by weight of agomelatine in Plasdone S630, and - 30% by weight of agomelatine in HPMC acetyl succinate.Forma amorfa estabilizada de agomelatina, de fórmula (I): **Fórmula** caracterizada porque la agomelatina está dispersada dentro de una matriz de la siguiente manera: - 30%, 40% o 50% en peso de agomelatina en Eudragit L100, - 30%, 35%, 40% o 50% en peso de agomelatina en Eudragit L100-55, - 30%, 35% o 40% en peso de agomelatina en Kollidon VA64, - 30%, 35% o 40% en peso de agomelatina en Soluplus, - 30% o 40% en peso de agomelatina en acetato-ftalato de polivinilo, - 30% en peso de agomelatina en Plasdone S630, y - 30% en peso de agomelatina en acetil succinato de HPMC.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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