TREATMENT OF HOT FLASH, VASOMOTOR SYMPTOMS, NIGHT SWEATS, ALZHEIMER'S DISEASE, LOSS OF COGNITIVE FUNCTION, MEMORY LOSS, AND DEMENTIA BY COMBINATION OF SEX STEROID PRECURSOR AND SELECTIVE ESTROGEN RECEPTOR MODULATOR
To provide treatment of Alzheimer's disease, loss of cognitive function, memory loss, and dementia by combination of sex steroid precursor and selective estrogen receptor modulator.SOLUTION: Disclosed is a novel method for reducing or eliminating the occurrence of hot flash, vasomotor symptoms and night sweats, while reducing the risk of acquiring breast cancer, uterine cancer or endometrial cancer and also causing a useful action further, by inhibiting occurrence of osteoporosis, hypercholesterolemia, hyperlipidaemia, atherosclerosis, high blood pressure, insulin resistance, Type 2 diabetes, muscle mass decrease, steatosis, Alzheimer's disease, loss of cognitive function, amnesia, or vaginal dryness, in warm-blooded animals including susceptible humans, the composition comprising administering an amount of sex steroid precursor, particularly a dehydroepiandrosterone (DHEA) and an antiestrogen drug, or a selective estrogen receptor modulator, particularly a benzopyran compound. Pharmaceutical compositions and kits for delivering active ingredients useful in the present invention are also disclosed.SELECTED DRAWING: None【課題】性ステロイド前駆体と選択的エストロゲン受容体モジュレーターとの組み合わせによるアルツハイマー病、認知機能の喪失、記憶喪失及び痴呆症の治療【解決手段】ある量の性ステロイド前駆体、特にデヒドロエピアンドロステロン(DHEA)及び抗エストロゲン剤又は選択的エストロゲン受容体モジュレーター、特にベンゾピラン化合物の投与を含む、感受性のあるヒトを含む温血動物における骨粗鬆症、高コレステロール血症、高脂血症、アテローム性動脈硬化症、高血圧症、インスリン抵抗性、2型糖尿病、筋肉量減少、脂肪症、アルツハイマー病、認知機能の喪失、記憶喪失又は膣乾燥の発生の阻害によって、乳癌、子宮癌又は子宮内膜癌の罹患リスクを低減し、また有益作用を更にもたらしつつ、ホットフラッシュ、血管運動症状及び寝汗の発生を低減又は排除するための新規方法。本発明に有用な、活性成分を送達するための医薬組成物及びキットも開示する。【選択図】なし
