A guide system for use with breakaway cables of a sprayer boom of an agricultural sprayer is provided that may include multiple guides for the cables. One of the guides may provide a barrier to physical contact between the cables and the other guide or other potential pinch points to eliminate instances of breakaway cable pinching. This may be done by way of a guide tube through which the cable extends, with the guide tube preventing physical contact between the cable and a pair of rollers of a roller guide.