(57)< Abstract > For example they are 41 integurin, obstruction method of connecting to that receptor of VCAM-1 and huiburonekuchin etc The chemical compound which obstructs the connection That kind of chemical compound is included, medicine activity the composition And in the above-mentioned shape or management of a diseased state where, 4 of that kind of chemical compound in the form of the formulation1 participates or use for preventing.α4β1インテグリンの例えばVCAM-1およびフィブロネクチンなどのそれの受容体への結合の阻害方法その結合を阻害する化合物そのような化合物を含む医薬的に活性な組成物ならびに上記の形でのあるいは製剤の形でのそのような化合物の、α4β1が関与する疾患状態の管理または予防のための使用。