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Compositions and methods for topical application and transdermal delivery of botulinum toxins
专利权人:
Jacob M. Waugh;Michael D. Dake
发明人:
Michael D. Dake,Jacob M. Waugh
申请号:
US11367642
公开号:
US09180081B2
申请日:
2006.03.03
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Improved formulations for transdermal delivery of botulinum toxin are disclosed. The formulations include, for example, botulinum toxin non-covalently associated with a positively charged backbone having branching or efficiency groups. The formulations also include a partitioning agent, oligo-bridge, or polyanion bridge, and may optionally contain a viscosity modifying agent. The formulations are designed for topical application onto the skin of a patient and may be used to treat wrinkles, hyperhidrosis, and other health-related problems. Kits for administration are also described.
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