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HIGH MOBILITY GROUP BOX I MUTANT
专利权人:
Stephen H. THORNE
发明人:
Stephen H. THORNE
申请号:
US16335515
公开号:
US20190209629A1
申请日:
2017.09.21
申请国别(地区):
US
年份:
2019
代理人:
摘要:
This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that codes for a variant HMGB1 protein. It provides, at least in part, that vaccinia viruses modified to contain nucleic acid encoding variant HMGB1 and that express a variant HMGB1 or a fragment thereof can achieve a synergistic effect in combination with chemotherapy. Further, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of various cancers.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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