The present invention relates, in some embodiments thereof, to devices, systems and methods for establishing a fluid passageway between vessels. In some embodiments, the invention provides a system that comprises a first vessel； a second vessel configured to be coupled to the first vessel； and a plunger locking mechanism disposed on the first vessel and configured to lock a plunger thereof and prevent the plunger from expelling content of the first vessel prior to an engagement with the second vessel, wherein the first and/or second vessel(s) comprise(s) an unlock mechanism configured to unlock the lock mechanism of the first vessel, and wherein at the time of or following the engagement between the first vessel and the second vessel, the unlock mechanism unlocks the lock mechanism of the plunger, allowing movement thereof and thereby a fluid transfer from the first vessel to the second vessel.
