БАРНШАЙД Лутц Др. (DE),ШВИР Зебастиан Др. (DE),БАРТОЛОМОЙС Иоганнес Др. (DE)
申请号：
RU2013114406/15
公开号：
RU2013114406A
申请日:
2011.09.01
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A pharmaceutical dosage form exhibiting a tensile strength of at least 500 H, said dosage form contains a pharmacologically active component (A), a physiologically acceptable polymer (B) obtained by polymerizing a monomer composition containing an ethylenically unsaturated monomer carrying an anionic functional group in protonated form or a physiologically acceptable salt thereof； a polyalkylene oxide (C) having a weight average molecular weight of at least 500,000 g / mol, wherein the content of polyalkylene oxide (C) s stavlyaet at least 20 wt%, based on the total weight of the formulation；. wherein the pharmacologically active component (A) is present in a controlled release matrix comprising a polymer (B) and polyalkylene oxide (C) .2. The pharmaceutical dosage form according to claim 1, wherein the pharmacologically active component (A) is an opioid. The pharmaceutical dosage form according to claim 1 or 2, wherein the anionic functional group is selected from carboxyl groups, sulfonyl groups, sulfate groups, and phosphoryl groups. The pharmaceutical dosage form according to claim 1 or 2, wherein the monomer composition comprises a monomer selected from acrylic acid, alkyl acrylates and alkyl alkacrylates, or a combination thereof. The pharmaceutical dosage form according to claim 1 or 2, wherein the monomer composition further comprises a cross-linking agent. The pharmaceutical dosage form of claim 5, wherein the cross-linking agent is selected from the group consisting of allyl sucrose, allyl pentaerythritol, divinyl glycol, divinyl polyethylene glycol, and diol and (meth) acrylic acid esters. Pharmaceutical1. Фармацевтическая лекарственная форма, проявляющая прочность на разрыв по меньшей мере 500 H, указанная лекарственная форма содержит- фармакологически активный компонент (A)；- физиологически приемлемый полимер (B), получаемый путем полимеризации мономерной композиции, содержащей этиленненасыщенный мономер, несущий анионную функциональную группу, в про
