ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy

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专利权人:

Acceleron Pharma Inc.

发明人:

Seehra, Jasbir,Lachey, Jennifer

申请号：

AU2020202406

公开号：

AU2020202406A1

申请日:

2020.04.06

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

#$%^&*AU2020202406A120200430.pdf#####ACTRIIB PROTEINS AND VARIANTS AND USES THEREFORE RELATING TO UTROPHIN INDUCTION FOR MUSCULAR DYSTROPHY THERAPY 5 ABSTRACT In certain aspects, the present invention provides compositions and methods for inducing utrophin expression in muscle with an ActRIIB protein as therapy for muscular dystrophy. The present invention also provides methods of screening compounds that 0 modulate activity of an ActRIIB protein and/or an ActRIIB ligand. 60

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