Vaccine can induce the formation of Antibodies targeting PCSK9 in vivo.Claim 1: a vaccine comprising at least a Peptide consisting of 9 to 25 amino acid residues to the Amino Acid Sequence x u00b9x u00b2x u00b3wx u2074x u2075x u2076rx u2077 (x u2078) u2098 (x u2079) u2099 (SEC ID no. 1) where x u00b9 is a residue of selected amino acid residues of the amino Group Acids not loaded, preferably selected from the group consisting of Sen, threonine, Valine and alanineX is a residue of amino acid selected from the group of amino acid residues not loaded, preferably selected from the group of isoleucine, Valine, Glycine, glutamine, and more preferably alanine, isoleucine, Valine, alanine and Glutamine, X is an amino acid residue selected d The Group of non charged amino acid residues, Selected, preferablyThe Group consists of Proline, threonine, alanine and Valine, Proline x u2074 is more preferably, a residue of amino acid selected from the group consisting of asparagine, glutamine and Sen, alanine, Aspartic acid, x u2075 is a residue of amino acid selected from the group consisting of leu Cina, Glycine, alanine, Aspartic acid, phenylalanine and tyrosine, Valine, Leucine, preferably,X u2076 is a residue of amino acid selected from the group of negatively charged amino acid residue, preferably a Hydrophilic amino acid residue selected from the group consisting of glutamic acid and Aspartic acid, x u2077 is a residue of amino acid selected from the group of R Esiduos of uncharged amino acids, preferably selected from the group consisting of isoleucineLeucine, alanine and threonine residue x u2078 is an amino acid selected from the group of non charged amino acid residue selected from the group consisting of threonine, Leucine, glutamine, alanine and Serine, x u2079 is x u00b9 u2070x u00b9 u00b9x u00b9 u00b2 or a truncated Fragment of C terminus of which is In 1 or 2 amino acid residues, x u00b9 u2070 is any amino acid residue,Preferably a residue of amino acid selected fr
