LA MOTTE-MOHS, Ross,SHAH, Kalpana,SMITH, Douglas, H.,JOHNSON, Lesile, S.,MOORE, Paul, A.,BONVINI, Ezio,KOENIG, Scott
申请号：
PH12017502222
公开号：
PH12017502222A1
申请日:
2017.12.05
申请国别(地区):
PH
年份:
2018
代理人:
摘要：
The present invention is directed to the anti -LAG-3 antibodies, LAG-3 mAb 1, LAG-3 mAb 2, LAG-3 mAb 4, LAG-3 mAb 5, and LAG-3 mAb 6, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to LAG-3 - binding molecules that comprise LAG-3 binding fragments of such anti-LAG-3 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such LAG-3-binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of detecting LAG-3, as well as methods of using molecules that bind LAG-3 for stimulating immune responses.
