Spraying to do the respective solution which in syringe 2 of pair (2a and 2b) is accommodated mixing and in spray head 30 of the organism organizational adhesive application instrument 1 which applies the organism organizational adhesive which becomes, to the affected part, 1st the solution which is accommodated in on the one hand syringe 2a is injected to specified injection direction injection mouth 42a and the solution which is accommodated in other syringe 2b equality with injection direction or 2nd it is injected to abbreviation identical direction to provide with injection mouth 42b, 2nd injection mouth 42b, 1st injection mouth 42a compared to the front of injection directionIt arranges. By this invention, spraying the occasion where it applies the organism organizational adhesive which becomes, to the affected part, to do simultaneously and with the 1st solution which is accommodated in the 1st syringe and the 2nd solution which is accommodated in the 2nd syringe be able to mix and be able to prevent the blockade of the injection mouth where the 1st and 2nd solution is injected, it is possible to apply the organism organizational adhesive intermittently securely.一対のシリンジ2(2a,2b)に収容されているそれぞれの溶液を噴霧し混合してなる生体組織接着剤を、患部に塗布する生体組織接着剤塗布器具1のスプレーヘッド30に、一方のシリンジ2aに収容された溶液が所定の噴射方向に噴射される第1の噴射口42aと、他方のシリンジ2bに収容された溶液が噴射方向と同一または略同一の方向に噴射される第2の噴射口42bとを設け、第2の噴射口42bを、第1の噴射口42aよりも噴射方向の前方に配置する。この発明により、第1のシリンジに収容された第1の溶液と、第2のシリンジに収容された第2の溶液とを同時に噴霧し混合してなる生体組織接着剤を、患部に塗布する際、第1および第2の溶液が噴射される噴射口の閉塞を防止でき、生体組織接着剤の断続的な塗布を確実に行うことができる。