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Human trophoblast stem cells and methods of therapeutic screening
专利权人:
Accelerated BioSciences Corp.
发明人:
Jau-Nan Lee,Tony Tung-Ying Lee,Yuta Lee
申请号:
US13909469
公开号:
US09335322B2
申请日:
2013.06.04
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Existence of human trophoblast stem (hTS) cells has been suspected but unproved. The isolation of hTS cells is reported in the early stage of chorionic villi by expressions of FGF4, FGFR-2, Oct4, Thy-1, and stage-specific embryonic antigens distributed in different compartments of the cell. hTS cells are able to derive into specific cell phenotypes of the three primitive embryonic layers, produce chimeric reactions in mice, and retain a normal karyotype and telomere length. In hTS cells, Oct4 and fgfr-2 expressions can be knockdown by bFGF. These facts suggest that differentiation of the hTS cells play an important role in implantation and placentation. hTS cells could be apply to human cell differentiation and for gene and cell-based therapies.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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