Qian Shi,Juan Zhang,Junzhuan Qiu,Xin Dong,Jiping Zha,Ziyong Sun
申请号：
US14679951
公开号：
US20150282460A1
申请日:
2015.04.06
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present disclosure provides an immuno-deficient animal useful as an animal model for a human disease, wherein the animal comprises: (a) functional human immune cells and (b) a human xenograft comprising a pathogenic human cell or tissue, wherein the human immune cells and the human xenograft meet at least one of the following criteria: i) the human xenograft expresses a threshold level of a therapeutic target for the human disease ii) the human immune cells match with the human xenograft for at least one human leukocyte antigen (HLA) marker and iii) the human xenograft cells expresses a desired level of the matched HLA marker. Also provides is a method of producing the animal model and use of the animal models.
