SIMMEN, KENNETH ALAN,施艾伦,施艾倫,DE KOCK, HERMAN AUGUSTINUS,戴寇克,戴寇克,RABOISSON, PIERRE JEAN-MARIE,雷伯森,雷伯森,LINDSTROEM, MATS STEFAN,史帝分,史帝分,KAHNBERG, PIA CECILIA,凯利亚,凱利亞,ANTONOV, DMITRY,安东诺,安東諾,NILSSON, KARL
申请号：
TW095127583
公开号：
TWI437993B
申请日:
2006.07.28
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
Inhibitors of HCV of formula (I)and the N-oxides , salts, and stereoisomers thereof, wherein the dashed line represents an optional double bond between atoms C7 and or C8,R1is hydrogen C1-6alkylR2is hydrogen or C1-6alkyl and n is 3, 4, 5, or 6 Pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I) are provided. Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.本發明係提供式(I)之HCV抑制劑,及其N-氧化物,鹽類,及立體異構物,其中虛線代表C7及C8原子間任意的雙鍵;R1為氫或C1-6烷基;R2為氫或C1-6烷基;且n為3,4,5,或6;含有化合物(I)之製藥組成物及製備化合物(I)的方法。本發明亦提供式(I)的HCV抑制劑與利脫納維(ritonavir)之生物可利用的組合物。
