The purpose of the present invention is to provide a substance which can inhibit the proliferation of oral bacteria and is safe for ingestion. Particularly, the usefulness of the combined use of a saccharide and a sugar alcohol is not found clearly yet. Provided is a combination of a saccharide and a sugar alcohol, which can inhibit the proliferation of oral bacteria. An oral bacteria proliferation inhibitor characterized by comprising galactose and sorbitol. This oral bacteria proliferation inhibitor is effective for the amelioration and prevention of periodontal disease.本發明係關於提供抑制口腔內細菌增殖之即使攝取亦無害之物質。尤其,對於併用糖與糖醇時之有效性,至今仍未明確,提供抑制口腔內細菌增殖之糖與糖醇之組合。含半乳糖及山梨糖醇為特徵之口腔內細菌之增殖抑制劑。關於本發明之口腔內細菌之增殖抑制劑係適用於改善及預防牙周病。
