Device for administering at least one active principle per oral mucosa, comprising: - a body (10), - a bulb (2) inserted into said body (10), said ampoule (2) preferably containing a solution hydro-alcoholic being able to dispose of an active ingredient already dissolved therein in a solution, preferably an aqueous-alcoholic solution, said ampoule (2) having on one side a single opening closed by a perforable lid (20), said ampoule (2) being provided with the side at its end (21) opposite said opening of a shank, - a cannula (11) provided with a dispensing orifice (110) for dispensing said at least one active principle on the oral mucosa, in particular the gingivo-jugal mucosa, said cannula being provided with a deformation at its base in the form of a lower reservoir called a "kangaroo pouch", said cannula (11) being able to conceal within it one or more active principle (s) (s) likely to be dissolved s by the solution issuing from the ampoule (2), - a perforator (12) for perforating said seal (20) and connecting the inside of said ampoule (2) with said cannula (11), - said body (10) having breaking means (31, 32) for breaking said tail formed at the opposite end (21) of the ampoule (2) simultaneously and / or after perforation of said seal (20) by said perforator (12). Dispositif d'administration d'au moins un principe actif par voie per-muqueuse buccale, comportant: - un corps (10), - une ampoule (2) insérée dans ledit corps (10), ladite ampoule (2) contenant préférentiellement une solution hydro-alcoolique pouvant disposer d'un principe actif s'y trouvant déjà dissout dans une solution, de préférence une solution hydro-alcoolique, ladite ampoule (2) comportant d'un côté une seule ouverture obturée par un opercule (20) perforable, ladite ampoule (2) étant munie du côté à son extrémité (21) opposé à ladite ouverture d'une queue, - une canule (11) pourvue d'un orifice de distribution (110) pour distribuer ledit au moins un princi
