COMPOUND, PHARMACEUTICAL COMPOSITION, METHODS FOR PREVENTING OR TREATING A DISEASE, DISORDER OR CONDITION, TO INCREASE HDL CHOLESTEROL LEVELS IN AN INDIVIDUAL, TO REDUCE LDL CHOLESTETOL LEVELS IN SERUM, IN A UNIQUE INDIVIDUAL UNDERSTANDING INDIVIDUAL, AND TO REDUCE CHOLESTEROL ABSORPTION IN AN INDIVIDUAL, AND, USE OF A COMPOUND.
RONALD CHARLES BERNOTAS,JOHN WILLIAM ULLRICH,JEREMY MARK TRAVINS,JAY E. WROBEL,RAYMAND J. UNWALLA
申请号：
BRPI0811091
公开号：
BRPI0811091A2
申请日:
2008.05.15
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
Disclosed are quinazoline-based modulators of Liver X receptors (LXRs) and related methods. The modulators include compounds of formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, W, W1, W2, W3, A, Ra, Ra&prime；, Rb, Rb&prime；, Rc, Rd, Rd&prime；, Re, Rf, Rg, Rh, Ri Rj, Rk, Rm, Rn, Ro, Rp, Rq, and n, can be, independently, as defined anywhere herein. In general, these compounds can be used for treating or preventing one or more diseases, disorders, conditions or symptoms mediated by LXRs.
