AURELIA LAPPERT,HANS-MICHAEL WOLFF,JOHANNES JOSEF LEONHARD,KRISTINA KASSNER,MARCO EMGENBROICH,WALTER MÜLLER,WILLI CAWELLO
申请号：
BR112015011729
公开号：
BR112015011729A2
申请日:
2013.11.21
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
1/1 Summary "Multi-Day Adhesive Infusion Device for Transdermal Rotigotine Delivery" The present invention relates to a transdermal therapeutic system comprising (a) a backing layer, (b) a self-adhesive matrix layer rotigotine-based solvent-based as the active ingredient, and (c) a release liner, wherein the self-adhesive matrix layer has a coating weight of about 75 to 400 g / m2 and comprises a reservoir layer containing about 9 to 25 wt% rotigotine based on the weight of the reservoir layer, a kit comprising two transdermal therapeutic systems of the present invention as well as a method for preparing the transdermal therapeutic system of the present invention. The present invention relates to a transdermal therapeutic system comprising rotigotine as the active ingredient for use in the treatment of patients suffering from parkins disease. Parkinson's syndrome, depression, fibromyalgia and restless leg syndrome and for use in the treatment or prevention of dopaminergic neuronal loss or cognitive impairment by transdermal administration of rotigotine once or twice a week, in which the transdermal therapeutic system comprises a backing layer, a self-adhesive solvent-based rotigotine-containing matrix layer as well as a release coating, and is adapted to allow transdermal administration of therapeutically effective amounts of rotigotine for at least 3 days.1/1 resumo “dispositivo de perfusão adesivo de vários dias para administração transdérmica de rotigotina" a presente invenção refere-se a um sistema terapêutico transdérmico, que compreende (a) uma camada de suporte, (b) uma camada de matriz auto-adesiva à base de solvente contendo rotigotina como o ingrediente ativo, e (c) um revestimento de liberação, em que a camada de matriz auto-adesiva possui um peso de revestimento de cerca de 75 a 400 g/m2 e compreende uma camada de reservatório contendo ao redor de 9 a 25 % em peso de rotigotina com base no peso da camada de reservatório, um kit que compreende dois sistem
